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New Peer-Reviewed Study Explores How Vitamins A and D Influence Cancer-Related Pathways

November 17, 2025

This study examines how vitamins A and D affect breast and colorectal cancer pathways and highlights protective and combined effects across multiple models. The work aligns with and informs FAI’s ongoing exploration of integrative frameworks in biology and nutrition.

A new article titled “Vitamins A and D and Their Combinations for Breast and Colorectal Cancers: Analysis of the Clinical, Epidemiological, Pre-Clinical and Transcriptomic Data” has been published in Pharmaceuticals (2025), a peer-reviewed journal from Molecular Diversity Preservation International (MDPI). The study was authored by Temitope O. Lawal, Bolanle A. Adeniyi, and Gail B. Mahady, all faculty members at the Retzky College of Pharmacy, University of Illinois Chicago. The First Analysis Institute of Integrative Studies provided conceptual guidance and funding support.


This publication continues an evolving line of interdisciplinary inquiry connecting integrative frameworks – the Enneagram and the Triune Consciousness “3-6-9” model – to biological and nutritional research. It builds on earlier theoretical work identifying structural patterns in the genetic code (Identifying the Enneagram in the Genetic Code) and on experimental studies conducted at the University of Chicago and the University of Illinois Chicago exploring how vitamins A and D interact in laboratory and animal models.


The Pharmaceuticals article synthesizes meta-analyses, pre-clinical, and transcriptomic data to assess how vitamins A and D levels influence breast and colorectal cancer pathways. Key findings include:


  • Vitamin A: Evidence of an inverse association with breast cancer risk and improved survival outcomes in certain populations.

  • Vitamin D: Consistent correlations with reduced breast cancer incidence, enhanced survival, and protective effects.

  • Colorectal Cancer: Clear evidence that vitamin D reduced both risk and mortality; conflicting results regarding vitamin A.

  • Combined Effects: Compelling evidence that vitamins A and D combinations may be more effective for the prevention and treatment of breast and colon cancers, due to their significant synergistic effects and the larger number of cancer-signaling pathways impacted.


Read the article:
www.integrativestudies.com/publications/mdpi-nov-2025

© 2025 by First Analysis Institute of Integrative Studies

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